Migraine, headache disorders, primary headache disorders Migraine, severe headache
Conditions
Interventions
Participants will undergo three LSCI sessions. On Day 1, saline will be applied to forehead reservoirs to test feasibility and signal quality. On Day 2, capsaicin solution will be applied to induce tr
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Signed written informed consent.Participant is currently responding to MySalvia therapy in the RELIEF study (defined as =30% reduction in monthly migraine days compared to baseline).Willing and able to comply with study requirements, including travel to Rotterdam
Exclusion criteria
Exclusion criteria: Skin conditions on the forehead that may interfere with measurementsSerious medical or psychiatric conditions that may compromise participation (e.g., HIV, hepatitis B/C, cancer, psychiatric disorders according to DSM-5 such as depression, schizophrenia, suicidality).History of allergy or sensitivity to capsicum fruits (e.g., chili peppers).Other: insufficient mastery of Dutch or English; current substance dependence (alcohol, illicit drugs, tranquilizers, narcotics, analgesics).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The total number of artefacts during LSCI measurements aggregated for Day 1 and Day 2, stratified by baseline and active stimulation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Optimal reservoir placement (based on artefact frequency) and dermal blood flow parameters in response to capsaicin with and without stimulation, including maximal response (?Emax) and area under the curve (AUC0–40). | — |
Countries
Netherlands
Contacts
Public ContactN.R.A. Bruijn
Erasmus MC, Universitair Medisch Centrum Rotterdam
Outcome results
None listed