Stroke, ischemic stroke, brain infarct, cerebrovascular accident, CVA, cerebral infarction Stroke
Conditions
Interventions
NA.
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Clinical diagnosis of acute ischemic stroke (first-ever or recurrent) admitted to the hospital within 1 week of symptom onset Age =18 yearsPresence of acute neurological deficit lasting more than 24 hoursDischarge destination directly home (with or without outpatient rehabilitation)Able to undergo brain-MRI within 1 week after stroke onset
Exclusion criteria
Exclusion criteria: At baseline:Pre-stroke dementia (known diagnosis of dementia or Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) >3.6Psychiatric or neurological disease other than the qualifying event with an active interference on cognition, as judged by a clinician Insufficient command of the Dutch language to undergo neuropsychological assessmentContra-indications to MRI (e.g., non-compatible pacemaker or implants, severe claustrophobia, cardiopulmonary disease)Condition interfering with participation in neuropsychological assessment (e.g., severe aphasia interfering with comprehension of test-instructions) Additional exclusion criteria based on MRI:No acute infarct visibleAlternative diagnosis for acute symptoms identified on imaging (e.g., brain tumor)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Presence or absence of PSCI based on multidomain neuropsychological assessment at 6 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient reported outcome measures (PROMs) on ability to- and satisfaction with participation in social roles and activities | — |
Countries
Netherlands
Contacts
Public ContactC. Didderen
Universitair Medisch Centrum Utrecht
Outcome results
None listed