Detecting a condition of the smallest brain vessels (the microvascular bed) using functional MRI
Conditions
Interventions
Philips 7 Tesla with surface receive coils.
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Stage 1: Healthy volunteers between the age >18 years and <65 years 2. Stage 2: Healthy volunteers in two age groups; 25-35 and 60-70 years (evenly distributed across groups). 3. Able and willing to give written informed consent. 4. Proper eye vision or proper eye vision using the MRI compatible glasses (lens types available: -6.5:0.5:6.5)
Exclusion criteria
Exclusion criteria: 1. Age <18 years or >70 years 2. Persons with reduced mental capacity 3. Pregnancy and a chance of being pregnant (as reported by the volunteer) 4. Not having a general practitioner 5. MRI contraindication e.g. cardiac pacemaker, implants not approved for MRI (see www.mrisafety.com), claustrophobia, tinnitus, metal objects attached to the body that cannot be removed (fillings and most of other dental works are allowed). Decision on the MRI contraindication is made according to the guidelines outlined in the MR safety document of the Department of Radiology which can be found in the attachment (“MRI Veiligheidsrichtlijnen LUMC (BPPC-protocol)”). 6. Epilepsy 7. Vascular, neurodegenerative or psychiatric disorder 8. Not willing to consent to inclusion in the public data base
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters of this project are quantitative measurements of hemodynamic parameters. Specifically, we will measure the hemodynamic response function across cortical depth during visual tasks. This will be performed for different fMRI contrasts in 2 scan sessions: GRE and SE BOLD, fVASO and f(vs)ASL resulting in multiparametric hemodynamic response functions. Primary endpoint of this study is to use these experimental blood volume and flow weighted hemodynamic response functions to simulate the BOLD fMRI signal with our realistic human vascular model. This will provide a better physiological underpinning of the BOLD signal for future use. These hemodynamic response functions will be quantified with amplitude (d%BOLD, d%CBV and d%CBF for the different contrasts resp.), onset, time-to-peak, time-to-baseline and full-width-at-half-max. | — |
Secondary
| Measure | Time frame |
|---|---|
| Having measured the primary outcomes, a secondary objective is to study the influence of age on these parameters potentially providing new insights in neuronal coupling and cerebrovascular health. | — |
Countries
Netherlands
Contacts
Public ContactE.C.A. Roefs
Leids Universitair Medisch Centrum
Outcome results
None listed