How does mechanical ventilation affect brain activity?

Unraveling the Effects of Mechanical Ventilation on Respiratory-Brain Coupling - Unraveling the Effects of Mechanical Ventilation on Respiratory Entrained Oscillations using EEG: Towards Brain-Protective Ventilation

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON58179

Enrollment

Registered

2025-04-01

Start date

2025-11-21

Completion date

Unknown

Last updated

2026-02-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventilator Associated Brain injury, Post Intensive Care Syndrome, ICU-Associated Cognitive Dysfunction Post-Intensive Care Syndrome

Interventions

Each ICU patient will undergo three high density electoencephalography (hdEEG) recordings under different ventilator conditions commonly used in clinical practice (Pressure Control Ventilation, Pressu

Eligibility

Age

16 Years to 99 Years

Inclusion criteria

Inclusion criteria: To be eligible to participate in this study, a participating patient must meet all of the following criteria:Aged 16 years or olderInvasively mechanically ventilatedPresence of spontaneous breathing activityNo to low sedation using general anaestheticsHemodynamically and respiratory stableCapable of unobstructed nasal and oral respiration     Healthy volunteers are not subject to these criteria. They must only meet the following inclusion criterium:Aged 16 years or olderCapable of unobstructed nasal and oral respiration 

Exclusion criteria

Exclusion criteria: Pre-existing neurological or cognitive disorders that may affect cortical activityTraumatic brain injuryHead wounds interfering with safe EEG cap placementPregnancy

Design outcomes

Primary

Measure	Time frame
The main study endpoint is the degree of respiratory-brain coupling during and after mechanical ventilation.  Respiratory-brain coupling will be quantified using EEG measures associated with brain connectivity, including: Functional connectivity (shown in Figure 3): Phase-phase coupling between the breathing rhythm and cortical activity (e.g. phase locking value, coherence) [1].Phase-amplitude coupling between the breathing rhythm and cortical activity (e.g. modulation index) [2]. Effective connectivity: Model-free measures (e.g. transfer entropy, directed phase lag index) [3].Model-based measures (e.g. granger causality between the breathing rhythm and cortical activity) [3] Watanabe T, Itagaki A, Hashizume A, Takahashi A, Ishizaka R, and Ozaki I. Observation of respiration-entrained brain oscillations with scalp EEG. Neuroscience letters 2023 Feb; 797. doi: 10.1016/J.NEULET.2023.137079. Available from: https://pubmed.ncbi.nlm.nih.gov/36657634/4Tort AB, Branka?ck J, and Draguhn A. Respiration-Entrained Brain Rhythms Are Global but Often Overlooked. Trends in neurosciences 2018 Apr; 41:186–97. doi: 10.1016/J.TINS. 2018.01.007. Available from: https://pubmed.ncbi.nlm.nih.gov/29429805/Cao J, Zhao Y, Shan X, Wei Hl, Guo Y, Chen L, Erkoyuncu JA, and Sarrigiannis PG. Brain functional and effective connectivity based on electroencephalography recordings: A review. Human Brain Mapping 2021 Feb; 43:860. doi: 10 . 1002 / HBM . 25683. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC8720201/	—

Measure

Time frame

The main study endpoint is the degree of respiratory-brain coupling during and after mechanical ventilation.  Respiratory-brain coupling will be quantified using EEG measures associated with brain connectivity, including: Functional connectivity (shown in Figure 3): Phase-phase coupling between the breathing rhythm and cortical activity (e.g. phase locking value, coherence) [1].Phase-amplitude coupling between the breathing rhythm and cortical activity (e.g. modulation index) [2]. Effective connectivity: Model-free measures (e.g. transfer entropy, directed phase lag index) [3].Model-based measures (e.g. granger causality between the breathing rhythm and cortical activity) [3] Watanabe T, Itagaki A, Hashizume A, Takahashi A, Ishizaka R, and Ozaki I. Observation of respiration-entrained brain oscillations with scalp EEG. Neuroscience letters 2023 Feb; 797. doi: 10.1016/J.NEULET.2023.137079. Available from: https://pubmed.ncbi.nlm.nih.gov/36657634/4Tort AB, Branka?ck J, and Draguhn A. Respiration-Entrained Brain Rhythms Are Global but Often Overlooked. Trends in neurosciences 2018 Apr; 41:186–97. doi: 10.1016/J.TINS. 2018.01.007. Available from: https://pubmed.ncbi.nlm.nih.gov/29429805/Cao J, Zhao Y, Shan X, Wei Hl, Guo Y, Chen L, Erkoyuncu JA, and Sarrigiannis PG. Brain functional and effective connectivity based on electroencephalography recordings: A review. Human Brain Mapping 2021 Feb; 43:860. doi: 10 . 1002 / HBM . 25683. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC8720201/

—

Secondary

Measure	Time frame
•    Baseline characteristics•    Physiological parameters	—

Countries

Netherlands

Contacts

Public ContactJ. Doorduin

Radboud Universitair Medisch Centrum

Jonne.Doorduin@radboudumc.nl+31650155757

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP) · Data processed: Feb 19, 2026