Chronic Obstructive Pulmonary Disease (COPD) Chronic lung disease
Conditions
Interventions
In this study, the included patients will receive a NAVA catheter in order to be able to measure the
electrical activity of the diaphragm (Edi). Placement of a nasogastric tube is considered standard
1) PS-NIV with 5 cm H2O support, 2) NAVA-NIV with 5 cm H2O
support, 3) PS-NIV with 10 cm H2O support and 4) NAVA-NIV with 10 cm H2O support. This study design
has been summarized in figure 1. During t
Sponsors
Bravis Ziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Adult patient COPD confirmed by spirometry Admission to the ICU department with AECOPD resulting in respiratory failure
Exclusion criteria
Exclusion criteria: Need for intubation Non-cooperative or patient with reduced consciousness (GCS <13) Neuromuscular disorders affecting diaphragmatic function (e.g. myasthenia gravis or ALS). Known diaphragmatic hernia or esophageal malformation Severe facial deformities preventing proper mask fitting for non-invasive ventilation. Contra-indications to nasogastric tube placement
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dyspnea; measured in Multidimensional Dyspnea Profile (MDP). | — |
Secondary
| Measure | Time frame |
|---|---|
| Difference in airway occlusion pressure at equal mean airway pressure in NAVA-NIV and PS-NIV as a marker of neuromuscular efficiency. End-tidal CO2 during NAVA-NIV and PS-NIV. Blood gas analysis. Patient preference for NAVA or PS – NIV. ICU length of stay Deterioration of AECOPD resulting in need for invasive ventilation. Reference outcomes of dyspnea scores in other AECOPD patients. | — |
Countries
Netherlands
Contacts
Public ContactD Ghantous
Bravis Ziekenhuis
Outcome results
None listed