Respiratory transfusion complications Shortness of breath due to blood transfusion
Conditions
Interventions
All patients developing a respiratory transfusion complication collected by participating blood banks. Cases will be matched to patients not developing a respiratory transfusion reaction on age, admit
Sponsors
Amsterdam UMC
Eligibility
Inclusion criteria
Inclusion criteria: All adult patients developing a transfusion complication as reported to hemovigilance agencies world-wide. Patients matched on transfusion type, age, sex, and admittance diagnosis, not developing a respiratory transfusion complication.January 2015 – present.
Exclusion criteria
Exclusion criteria: Local objection of patients to sharing data of materials for research purposes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of different types of respiratory transfusion complications related to specific blood product types and clinical parameters (e.g., mortality, risk factors). As well as the occurrence of anti–human leukocyte antigen class I/II antibodies, anti–human neutrophil antigen antibodies or non-HLA antibodies in patient and recipient samples. In addition, the influence and biological effects of plasma, micro-particles, lipids and other storage products with regard to respiratory transfusion complications will be determined. | — |
Secondary
| Measure | Time frame |
|---|---|
| This study is a descriptive study for research purposes and only includes objective data collected as part of routine care including waste material. Only standard proceedings will be performed. This study does not result in any risk, interventions or burdens to patients and/or family. | — |
Countries
Australia, Belgium, Canada, Denmark, France, Germany, Netherlands, Turkey, United Kingdom, United States
Contacts
Public ContactA.L> Peters
Amsterdam UMC
Outcome results
None listed