Coronary artery disease, myocardial ischemia Heart disease caused by coronary atherosclerotic stenosis
Conditions
Interventions
If the initial scan shows abnormalities, it will be repeated after proper adherence to preparation protocols (abstinence from caffeine, xanthine derivatives, and medications). Patients act as their ow
Sponsors
Spaarne Gasthuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patiënten van 18 tot 80 jaar.Verdenking op ischemisch hartlijden, verwezen voor rubidium-82 myocard perfusie PET-CT met farmacologische stress middels regadenoson.Onvoldoende voorbereiding volgens standaardprotocol (inname van cafeïne, theïne, chocolade, energiedrank, banaan of doorgebruik van medicatie zoals calciumantagonisten, nitraten).In staat en bereid om schriftelijke geïnformeerde toestemming te geven.
Exclusion criteria
Exclusion criteria: Contraindications for regadenoson, such as bronchospastic disease or severe hypotension.Known hypersensitivity or allergy to regadenoson or related substances.Use of theophylline or dipyridamole that cannot be safely discontinued.Simultaneous use of multiple interfering substances (e.g., both caffeine and medication) that prevents reliable interpretation.Pregnant or breastfeeding women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of normal scans in patients with suboptimal preparation (e.g., intake of caffeine, theine, or medications), indicating that the diagnostic performance of the scan was not compromised.Difference in quantitative myocardial blood flow measurements (stress flow, rest flow, and flow reserve) in patients with abnormal initial scans, comparing the initial scan with the follow-up scan after proper preparation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation between the estimated amount of caffeine or theine intake (in milligrams, based on standardized values per product) and differences in myocardial blood flow measurements (stress, rest, and flow reserve).Correlation between the time interval between last intake of interfering substances and scan results, assessing whether a shorter abstinence period (e.g., <12 hours) is associated with lower myocardial stress, rest, and flow reserve.Classification of participants into light (0–1 cup/day), moderate (2–3 cups/day), or heavy (>3 cups/day) consumers of caffeine-containing substances. Assessment of variation in myocardial blood flow results across these categoriesIn patients with an initial abnormal Rb-82 PET-CT scan, compare myocardial blood flow parameters (stress, rest, and flow reserve) between the first scan (with continued use of interfering medications such as nitrates or calcium antagonists) and the follow-up scan after proper medication cessation. | — |
Countries
Netherlands
Contacts
Public ContactJJ Boer
Spaarne Gasthuis
Outcome results
None listed