Osteoarthritis and meniscus lesions Knee arthrosis and rupture in the meniscus
Conditions
Interventions
Not applicable.
Sponsors
University of Twente
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Group 1: Non-impaired individualsAged between 18 and 70;Ability to independently perform different activities of daily living, including static posturing, overground walking, running, and stepping down from a platform for about 1.5 hours including breaks. Group 2: Individuals with knee osteoarthritis with meniscus lesions but without a meniscus implant Clinical diagnosis of knee OA; OA related complaints and/or radiographic modifications in at least one other joint group; Pain during movement assessed on a NRS = 3;Age = 18 yearAbility to independently perform different activities of daily living, including static posturing, overground walking, running, and stepping down from a platform for about 1.5 hours including breaks. Group 3: Individuals with knee osteoarthritis and a meniscus implantUnderwent medial or lateral meniscectomy;Received a meniscal implant;Limited knee osteoarthritis classified as Kellgren-Lawrence (KL) grade < 3;Neutral joint alignment (+/- 5 degrees);18-70 years;No relevant comorbidities;Ability to independently perform different activities of daily living, including static posturing, overground walking, running, and stepping down from a platform for about 1.5 hours including breaks. Group 4: Individuals with a transtibial amputation using a bone-anchored prosthesisTranstibial bone-anchored prosthesis users;Unaided walking;Activity level between K3 and K4;18-70 years;BMI<35;No osteoarthritis or pain in both knees;No relevant comorbidities;Ability to independently perform different activities of daily living, including static posturing, overground walking, running, and stepping down from a platform for about 1.5 hours including breaks.
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study:Not willing to provide written informed consent;Not able to follow instructions in Dutch or English;Immune-mediated inflammatory disease (IMID) of the joints;Scheduled for joint replacement surgery or osteotomy at time of inclusion;Joint replacement surgery in the past;Clinical diagnosis of fibromyalgia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters is the cartilage stress distribution in the knee as determined by the finite element models of the individuals. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome parameters are:Knee joint kinematics, as recorded during the instrumented gait analysis measurements, during the four different measured activities;Knee joint forces, as calculated through musculoskeletal modelling, during the four different measured activities;Muscle activity patterns, as recorded during the instrumented gait analysis measurements, during the four different measured activities. | — |
Countries
Netherlands
Contacts
Public ContactE.C. Prinsen
Roessingh Centrum voor Revalidatie
Outcome results
None listed