Neurocognitive impairment cognitive problems, memory and concentration problems
Conditions
Interventions
Paediatric patients aged 6–18 years who exhibit neurocognitive impairment and do not meet physical activity guidelines. This study will start by including children with congenital heart disease who un
Sponsors
Amsterdam UMC
Eligibility
Age
2 Years to 17 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a participant must meet all of the following criteria:Does not meet the physical activity guideline (at least one hour of moderate-to-vigorous intensity physical activity daily, including muscle- and bone-strengthening activities at least three times per week);Has a neurocognitive functioning impairment (<5th percentile in at least 1 neurocognitive domain);Experiences neurocognitive problems as reported by parents;Is fluent in Dutch and inhabitant of the Netherlands. Specific for children with congenital heart disease:Underwent open-heart surgery before the age of one year;Is aged 6–18 years at the time of inclusion in the study;Has a physical cardiovascular fitness deficit (impaired exercise tolerance) as measured by VO2 max (< -1 SD).
Exclusion criteria
Exclusion criteria: A potential participant who meets any of the following criteria will be excluded from participation in this study:Absence or withdrawal of written informed consent;Contraindications for physical activity as assessed by treating physician;Inability to comprehend testing instructions;Patient had opt-out for re-use of clinical data for research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is neurocognitive functioning, measured in seven domains: Speed, Stability, Attention & Control, Memory, Verbal Working Memory, Visual Working Memory and Visuomotor Integration. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints include physical cardiovascular fitness, physical activity, behavioural and emotional functioning, sleep quality and self-esteem. | — |
Countries
Netherlands
Contacts
Public ContactJ. Oosterlaan
Amsterdam UMC
Outcome results
None listed