Graves' Disease Graves' Disease, hyperthyroidism, overactive thyroid
Conditions
Interventions
This study has no investigational product, the only invasive intervention is the venous blood draw. 
Sponsors
Amsterdam UMC
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject with GD must meet all of the following criteria:=18 years oldDiagnosis of GD according to specialized clinician Elevated TRAb levels above upper reference limit in laboratory used at diagnosisGD onset or recurrence diagnosed within the last 4 months prior to inclusionAbility to provide informed consentAbility to understand Dutch or English In order to be eligible to participate in this study, a non-autoimmune hyperthyroidism control subject must meet all of the following criteria:=18 years oldAbility to provide informed consentAbility to understand Dutch or EnglishDiagnosis of non-autoimmune hyperthyroidism (toxic adenoma or toxic multinodular goiter) according to specialized clinician In order to be eligible to participate in this study, a healthy control subject must meet all of the following criteria:=18 years oldAbility to provide informed consentAbility to understand Dutch or EnglishConsider themselves healthy
Exclusion criteria
Exclusion criteria: A potential subject with GD or non-autoimmune hyperthyroidism who meets any of the following criteria will be excluded from participation in this study:Active infection at the time of inclusion Antibiotic or proton-pump inhibitor use in the last 3 monthsUnwillingness to donate feces, urine and/or bloodAbsence of large bowel (ie colostomy)Previous thyroidectomy or ablative treatment with radioactive iodineUse of the following drugs that can interfere with thyroid function:AmiodaroneLithiumIodine or iodide supplements PregnancyActive treatment of malignancy A potential healthy control who meets any of the following criteria will be excluded from participation in this study:Active infection at the time of inclusion Antibiotic or proton-pump inhibitor use in the last 3 monthsUnwillingness to donate feces, urine and/or bloodAbsence of large bowel (ie colostomy)Previous thyroidectomy or ablative treatment with radioactive iodineUse of the following drugs that can interfere with thyroid function:AmiodaroneLithiumIodine or iodide supplements ThiamazolLevothyroxineLiothyroninePregnancyActive treatment of malignancy
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Gut microbiome compositionDNA analysis for HLA subtype, specific polymorphisms associated with a higher risk of GD recurrence and specific polymorphisms associated with altered thyroid hormone metabolism. Identification of gut microbes that are potentially capable of triggering GD in the gut microbiome of GD patients using computational tools and validating the immune response to these microbes in vitro using patient-derived T-cells.Urinary iodide and thyroid hormone concentrations | — |
Primary
| Measure | Time frame |
|---|---|
| Fecal and plasma thyroid hormone concentrations.Concentrations of auto-antibodies against the thyroid receptor (TRAbs) in plasma | — |
Countries
Netherlands
Contacts
Public ContactA.H. Spek
Amsterdam UMC
Outcome results
None listed