olfactory dysfunction, olfactory impairment, smell dysfunction, anosmia, hyposmia, dysomia, trigeminal nerve dysfunction, pituitary adenoma smell problems, trigeminal nerve problems, pituitary tumors
Conditions
Interventions
None listed
Sponsors
UZ Leuven
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Voluntary written informed consent of the participant or their legally authorized representative has been obtained prior to any screening proceduresAdults = 18 yearsIndication of Endoscopic Endonasal Skull Base Surgery (EESBS) for medical reasons
Exclusion criteria
Exclusion criteria: Participant has a history of previous Endoscopic Endonasal Skull Base Surgery (EESBS)Pre-existing anosmia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of olfactory dysfunction as assessed by the Sniffin’ Sticks test.Severity of intranasal trigeminal dysfunction as assessed by the Ammonium Sticks.Severity of subjective reporting of olfactory dysfunction as assessed by a questionnaireInvestigation by histomolecular analysis of the mucosa of the posterodorsal part of the septum removed during surgery (surgical waste tissue). | — |
Secondary
| Measure | Time frame |
|---|---|
| Demographical dataTumour typeExtension of approachReconstruction technique of dural defectPeak Nasal Inspiratory Flow resultsLund-Kennedy endoscopy scores as assessed by nasal endoscopy | — |
Countries
Belgium, Netherlands
Contacts
Public ContactM.C. Kleijwegt
Leids Universitair Medisch Centrum
Outcome results
None listed