Complex Regional Pain Syndrome, CRPS Complex Regional Pain Syndrome, CRPS
Conditions
Interventions
No investigational intervention is performed. The study reuses existing clinical data from the electronic medical record, including demographics, pain scores, dosing logs, laboratory results, and adve
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Age = 18 years at the time of the first esketamine admission.Diagnosis of Complex Regional Pain Syndrome (CRPS) according to the International Association for the Study of Pain (IASP) “Budapest Criteria,” or previously met these criteria and is now classified as “CRPS with Remission of Some Features.”Received at least two continuous intravenous esketamine courses as an inpatient at Erasmus MC within the past 16 years (March 1, 2010 – July 1, 2026).
Exclusion criteria
Exclusion criteria: Documented objection (opt-out) to the use of medical records for research purposes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in pain relief (difference between baseline and day-7 pain scores) between first and subsequent esketamine courses.Duration of analgesia (time from discharge to recurrence of pain or next course). | — |
Secondary
| Measure | Time frame |
|---|---|
| Relationship between inter-course interval, cumulative esketamine exposure, and analgesic outcome.Incidence of hepatotoxicity (ALT/AST > 3× upper limit of normal).Influence of CRPS phenotype on treatment response. | — |
Countries
Netherlands
Contacts
Public ContactJ. Brink
Erasmus MC, Universitair Medisch Centrum Rotterdam
Outcome results
None listed