CRC, AAD, NAAD, Serrated polyps Colorectal cancer, polyps
Conditions
Interventions
The time between colonoscopy and FIT (FIT is a quantitative stool test (47 µg Hb/g stool))
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: The target group for this study includes individuals who participated in the national CRC screening program and had an positive FIT result followed by a negative colonoscopy 2 or 5 years ago (calculated from 2025). Individuals who participated in the national CRC screening program 10 years ago belong to the control group and screened occurring to regular care by the screening organization. The inclusion criterion is age until 75 years old.
Exclusion criteria
Exclusion criteria: Age = 75
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. FIT referral rate (number of FITs positives) per interval (2, 5 of 10 years) 2. Detection rate of FIT 3. Positive predictive value of FIT per interval based on old definitions3. Positive predictive value of FIT per interval based on new definitions | — |
Secondary
| Measure | Time frame |
|---|---|
| 3. Association between sex, age, FIT Hb concentration in FIT in previous invitation rounds, and FIT Hb concentration in current invitation rounds in relation to the yield per invitation round 4. Perception and experience of individuals with regard to acceptability and willingness to participate with screening at different invitation intervals. 5. Long-term effects such as (incremental) costs, quality-adjusted life years, the required colonoscopy capacity per invitation interval | — |
Countries
Netherlands
Contacts
Public ContactE.E.C. Rijnders
Erasmus MC, Universitair Medisch Centrum Rotterdam
Outcome results
None listed