Inflammation in tinnitus and hearing loss following microvascular decompression

INFLAMMATION IN TINNITUS AND HEARING LOSS FOLLOWING MICRO-VASCULAR DECOMPRESSION FOR NEUROVASCULAR COMPRESSION SYNDROMES– A PILOT STUDY – - The role of inflammation in tinnitus and hearing change following microvascular decompression for Neurovascular compression syndromes

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON58041

Enrollment

Registered

2025-03-23

Start date

2026-02-18

Completion date

Unknown

Last updated

2026-03-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tinnitus: Ringing in the ears, ear noise, auditory buzzing, ear ringing, phantom sound Hearing loss: daefness, hearing impairment, hearing problems, Hearing alteration

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Trigeminal neuralgia and hemifacial spasm patients undergoing microvascular decompression.

Exclusion criteria

Exclusion criteria:  History of previous surgery in the cerebellopontine angle.Diagnosis of an inflammatory disease or use of anti-inflammatory medication.Presence of an autoimmune disease.Diagnosis of a neurodegenerative disease.Current or history of malignancy.Chronic ear disease.Hematologic disease.Psychiatric disease.Pregnancy.Presence of an infectious disease or hyperpyrexia at the time of surgery or at the time of the 6 weeks follow up appointment.

Design outcomes

Primary

Measure	Time frame
Primary endpointsDifference in blood inflammatory marker levels measured in the immediate postoperative period and at 6 weeks postoperatively between patients who develop postoperative tinnitus and those who do not.Difference in CSF and CP inflammatory marker levels between patients who develop postoperative tinnitus and those who do not.Change in blood inflammatory marker levels from baseline to the immediate postoperative period and to 6 weeks postoperatively in patients who develop postoperative tinnitus.	—

Measure

Time frame

Primary endpointsDifference in blood inflammatory marker levels measured in the immediate postoperative period and at 6 weeks postoperatively between patients who develop postoperative tinnitus and those who do not.Difference in CSF and CP inflammatory marker levels between patients who develop postoperative tinnitus and those who do not.Change in blood inflammatory marker levels from baseline to the immediate postoperative period and to 6 weeks postoperatively in patients who develop postoperative tinnitus.

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Secondary

Measure	Time frame
Secondary endpointsDifference in blood inflammatory marker levels measured in the immediate postoperative period and at 6 weeks postoperatively between patients who develop postoperative HL and those who do not.Difference in CSF and CP inflammatory marker levels between patients who develop postoperative HL and those who do not.Change in blood inflammatory marker levels from baseline to the immediate postoperative period and to 6 weeks postoperatively in patients who develop postoperative HL.	—

Measure

Time frame

Secondary endpointsDifference in blood inflammatory marker levels measured in the immediate postoperative period and at 6 weeks postoperatively between patients who develop postoperative HL and those who do not.Difference in CSF and CP inflammatory marker levels between patients who develop postoperative HL and those who do not.Change in blood inflammatory marker levels from baseline to the immediate postoperative period and to 6 weeks postoperatively in patients who develop postoperative HL.

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Countries

Netherlands

Contacts

Public ContactL.B.M. Albakri

Universitair Medisch Centrum Groningen

l.b.m.albakri@umcg.nl0642506879

Outcome results