Centrifugation Conditions Shape the Regenerative Properties of Platelet-Rich Fibrin

The Science of Spin: How Centrifugation Conditions Shape the Regenerative Properties of Platelet-Rich Fibrin - Centrifugation Conditions Shape the Regenerative Properties of Platelet-Rich Fibrin

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON58035

Enrollment

Registered

2025-02-26

Start date

2025-10-01

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tissue Regeneration , Wound Healing

Interventions

Blood samples will be collected via peripheral venipuncture using a double-wing cannula. In the pilot study, 60 ml of blood will be collected per participant, distributed into 6 centrifugation tubes (

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: - male and female participants - age between 18 and 64, - no previous medical history; ASA1, and - no recent use of anticoagulants or antibiotics.

Exclusion criteria

Exclusion criteria: - smokers, - participants with a history of anti-coagulant or anti-inflammatory drugs in the last 3 months, - systemic diseases or having a history of any infection or antibiotic therapy in past 6 months, or - consent form couldn’t be obtained

Design outcomes

Primary

Measure	Time frame
Primary endpoint consists of the pattern and level of cumulative growth-factor release (e.g. PDGF-AA, PDGF-BB, VEGF, TGF-ß1, EGF, IGF-1).	—

Secondary

Measure	Time frame
Secondary endpoints include tensile strength, stiffness of PRF membranes, and cell viability.	—

Countries

Netherlands

Contacts

Public ContactMN Helder

Amsterdam UMC

m.helder@amsterdamumc.nl0617332328

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)