HBV
Conditions
Interventions
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: No signs of relevant disease • Previous chronic HBV infection (6 months or more HBsAg+ in the last 10 years) • Undetectable HBsAg levels • Undetectable HBV DNA levels • Ability to provide written informed consent
Exclusion criteria
Exclusion criteria: • Females who are pregnant or breast-feeding. • Participants with an insurmountable language barrier due to which it is impossible to perform correct and complete information. • An organic brain syndrome or other significant psychiatric abnormality which would compromise the ability to give informed consent. • History or other evidence of severe illness, malignancy or any other condition which would make the participant, in the opinion of the investigators, unsuitable for the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Phenotyping B and T cells of individuals who have achieved HBV functional cure using flow cytometry. | — |
Secondary
| Measure | Time frame |
|---|---|
| Determine RNA expression profiles of HBV specific B and T cells from individuals who have recovered from chronic HBV infections. | — |
Countries
Netherlands
Contacts
Public ContactW Hamerslag-de Groot
Erasmus MC, Universitair Medisch Centrum Rotterdam
Outcome results
None listed