Carotid artery disease
Conditions
Interventions
Not applicable.
Sponsors
Amsterdam UMC
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a participant must meet all of the following criteria:Adult individuals aged 18 years or older.Presence of atherosclerotic plaque in at least one carotid artery, as identified by prior CT angiography or carotid ultrasound.Plasma Lp(a) level determined at the screening visit, as measured by the Central Laboratory of the Amsterdam UMC:High-Lp(a) group: Lp(a) =125 nmol/LLow-Lp(a) group: Lp(a) <50 nmol/LCapable of safely undergoing MRI with gadolinium contrast.Willing and able to provide written informed consent.
Exclusion criteria
Exclusion criteria: A potential participant who meets any of the following criteria will be excluded from participation in this study: History of ipsilateral carotid revascularization (e.g., carotid endarterectomy or stenting).Active infection, autoimmune or systemic inflammatory disease, or malignancy (excluding localized skin cancer) that could confound imaging or inflammatory readouts, as judged by the investigator(s).Severe claustrophobia, precluding successful study participation.Inability to remain supine, precluding successful study participation.Presence of ferromagnetic implants.Presence of a pacemaker or implantable cardioverter-defibrillator (ICD).Renal impairment defined as eGFR <30 mL/min/1.73 m².Known severe allergic reaction to gadolinium-based contrast agents.Current pregnancy or breastfeeding.Any other condition or circumstance that, in the opinion of the investigator, would make the participant unsuitable for the study or interfere with the interpretation of the results.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary parameter is Ktrans, a DCE-MRI–derived marker of plaque neovascularization. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures include plaque volume, degree of carotid stenosis, lipid core volume, and other DCE-MRI kinetic parameters | — |
Countries
Netherlands
Contacts
Public ContactM.E. Annink
Amsterdam UMC
Outcome results
None listed