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Clinical comparison of children with CVI

Clinical comparison of a test-battery for the assessment of visual information processing in children with Cerebral Visual Impairment - Clinical comparison of a test-battery for the assessment of visual information processing in children with Cerebral Visual Impairment

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON57964
Enrollment
370
Registered
2025-03-19
Start date
2025-10-06
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebral visual impairment, cortical visual impairment, visual processing disorder

Interventions

The Assessment of Visual Information Processing in Children test-battery (AVIP-C)

Sponsors

Koninklijk Visio
Lead Sponsor

Eligibility

Age
2 Years to 11 Years

Inclusion criteria

Inclusion criteria: Two groups of children will be included; Group A) Children with a suspicion of CVI Group B) Children without CVI, without other neurodevelopmental disorders, and without visual impairment (neurotypical control group).Inclusion criteria for children with a suspicion of CVI (group A):Children between the ages of 6-12 that are referred to Bartiméus or Royal Visio with a suspicion of CVIAttending an elementary schoolChildren with an IQ of 70 or above. Inclusion criteria of control-group (group B):Children between the ages of 6-12 years without (suspicion) of CVI. We will include brothers, sisters, family, or friends of the children that are included in the study. These children will be matched for age, socio-economic, and parental country of origin of the parent(s) to the children with suspected CVI.Attending an elementary schoolIf not enough control-children can be matched, we will contact an elementary school to match the children in group A.Children with a presumed IQ of 70 or above

Exclusion criteria

Exclusion criteria: For children with a suspicion of CVI (group A):Children with a visual acuity below 0.1Children with severe ocular pathologiesFor neurotypical control children (group B)Children with a visual acuity below 0.1Children with severe ocular pathologiesChildren born prematurely (gestational age below 37 weeks)Children with motor problemsChildren with low birthweight (birthweight below 1500 gram)Children with neurological abnormalities such as cerebral palsy, epilepsy, hydrocephalus, periventricular leukomalacia, pregnancy/birth complications, traumatic brain injury or brain tumour.Children with a genetic disorder that impacts the brain or the ocular system.Children with developmental- behavioural- or learning disorders (e.g. ASD, ADHD, DCD, dyslexia). 

Design outcomes

Secondary

MeasureTime frame
The secondary study parameters consist of medical status and behavioural functioning. The end-point of the study is a fitting model to accurately and sensitively predict whether children have CVI. The specifics of the end-points are explained in chapter 7 (statistical analysis).Medical status:Gestational ageBirthweightNeurological findingsCVI Diagnosis (the determination of this diagnosis is described in chapter 5.2; procedures)Near visual acuityFar visual acuityVisual field restrictionsNystagmusStrabismusCrowding Ratio NearCrowding Ratio FarBehavioural functioning:IQ-scoreADHD-screeningDevelopmental Coordination Disorder-screeningASD-screeningCVI-screeningsAcademic achievement

Primary

MeasureTime frame
The main study parameters consist of age-normed z-scores for the higher order visual functions on the AVIP-C test-battery. The end-point of the study is a fitting model to accurately and sensitively predict whether children have CVI. The specifics of the end-points are explained in chapter 7 (statistical analysis). Functions to be tested by the AVIP-C test-battery:Global Visual Selective AttentionLocal visual selective attentionShifting between global and local visual selective attentionVisal spatial functionVisual identification functionVisuomotor functionVisual short-term memoryVisual long-term memoryVisual working memoryVisual processing speed

Countries

Netherlands

Contacts

Public ContactR Schraauwers

Bartiméus

rschraauwers@bartimeus.nl06-38403518

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)