PISA

Procalcitonin in Saliva as a Potential Non-Invasive Biomarker in the Evaluation of Infection Risk in Neonates - PISA

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON57954

Enrollment

Registered

2025-03-18

Start date

2026-03-05

Completion date

Unknown

Last updated

2026-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Early Onset Neonatal Sepsis Bacterial Infection in Newborn

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: Procalcitonin serum measurement in routine care as part of early onset sepsis risk assesment 

Exclusion criteria

Exclusion criteria: Severe vomiting Oral defects interfering with saliva collection 

Design outcomes

Primary

Measure	Time frame
Correlation between saliva procalcitonin and serum procalcitonin	—

Secondary

Measure	Time frame
- Correlation between saliva procalcitonin level and infection (positive culture, neonatal sequential organ failure assessment score, level of respiratory support) - Intraclass correlation coefficient between saliva C-reactive protein and serum C-reactive protein	—

Countries

Netherlands

Contacts

Public ContactT.B. Robles

Erasmus MC, Universitair Medisch Centrum Rotterdam

t.robles@erasmusmc.nl+31 10 704 0704

Outcome results