Aging, Muscle health, Metabolic health, Overweight/Obesity Aging, Muscle Health, Metabolic Health, Overweight/Obesity
Conditions
Interventions
Participants are asked to consume a nutritional supplement mix or control product daily for 4 weeks. Participants are randomly assigned to the intervention order.
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Participants provide signed and dated written informed consent prior to any study specific procedures Aged 60-80 yearsBody mass index (BMI) 25-35 kg/m2Sedentary lifestyle (not more than 2 hours of structured physical activity per week in the past 3 months)Stable dietary habits (no weight loss or gain > 5 kg in the past 3 months) Healthy (as determined by dependent physician based on medical questionnaire)Regular sleeping habits (7-9h of daily sleep)
Exclusion criteria
Exclusion criteria: Type 2 diabetesParticipants with active congestive heart failure and/or severe renal and or liver insufficiencyUncontrolled hypertensionAlcohol consumption of >3 servings per day for men and >2 servings per day for womenUnstable body weight (weight gain or loss > 5 kg in the last 3 months) or intention to lose weightParticipants who are on an intermittent fasting dietPrevious enrolment in a clinical study with an investigational product during the last 3 months or as judged by the investigator which would possibly hamper our study resultsSignificant food allergies/intolerance (seriously hampering study meals or study product)Participants who do not want to be informed about unexpected medical findingsBlood donation during or within 2 months prior to the study Disturbances in circadian rhythm determined with the follow criteria:Extreme early bird or extreme night person (score =30 or =70 on MEQ-SA questionnaire)Heavily varying sleep-wake rhythm Night shift work during last 3 monthsTravel across > 1 time zone in the last 3 monthsHigh daily caffeine intake > 400mg caffeine daily (more than 4 cups of coffee or energy drinks)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary study objective is delta respiratory exchange ratio (from 23:00 till 04:00) (indirect calorimetry) | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary study objective is skeletal mitochondrial function | — |
Countries
Netherlands
Contacts
Public ContactJ. Hoeks
Universiteit Maastricht
Outcome results
None listed