HIV, gut barrier function, systemic inflammation, functional immunology Immunity and intestinal inflammation
Conditions
Interventions
The ABB C1® 
dietary supplement is based on S. cerevisiae 
with added sweeteners. Each sachet contains 233 mg S. cerevisiae 
mineral yeast and 517 mg S. cerevisiae 
beta-glucans. Placebo consists of mainly mannitol and maltodextrin in the exact same form as the ABB C1® supplement. Participants will consume one stick daily with food or drink for 6 weeks. 
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Adult cis-gender males above 18 years of ageDocumented HIV-1 infectionon cART =6 months HIV-RNA load <40 copies/mL in latest measurement Latest CD4+ T-cell count = 200 cells/mm3 in latest measurementBeing participant of 2000HIV studyThe control subjects without HIV should be cis-gender males above 18 years of age.
Exclusion criteria
Exclusion criteria: No informed consentInsufficient communication because of language or other problemsActive hepatitis B/C or signs of acute infections or other acute conditionsOral antibiotics use in the past 3 monthsVaccination in the month prior to inclusion, or planned vaccination during course of the study Use of other prebiotic or probiotic supplementationUse of systemic anti-inflammatory or immunomodulatory drugs, such as biologics or corticosteroids
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters of this study include whole blood hemocytometer data, ex vivo cytokine production by peripheral blood mononuclear cells (PBMCs) upon stimulation with a panel of stimuli, Olink plasma proteomics for circulating inflammatory and gut barrier function markers, and fecal calprotectin levels. | — |
Secondary
| Measure | Time frame |
|---|---|
| Beta-glucan level in blood; neutrophil activation, ROS production and killing capacity | — |
Countries
Netherlands
Contacts
Public ContactTJW Otten
Radboud Universitair Medisch Centrum
Outcome results
None listed