SPARC-TBI

A Study on the Pathophysiology of Augmented Renal Clearance in patients with Traumatic Brain Injury - Pathophysiology of augmented renal clearance

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON57922

Enrollment

Registered

2025-03-26

Start date

2026-05-13

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Traumatic brain injury, infection, augmented renal clearance Traumatic brain injury, infection, increased renal function

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Age >17 and = 75 yearsBeing admitted to the Intensive Care with severe traumatic brain injury (GCS 3-8)Receiving ceftriaxone antibiotic as part of the SDD regime

Exclusion criteria

Exclusion criteria: No informed consent obtained from patient or legal representativeUrine creatinine clearance < 30 ml/min or anuriaKnown renal artery stenosisPatients with septic shock Patients with cardiogenic shockPatients with haemorrhagic shockUse of diuretics (including mannitol), beta-blockers, ACE-inhibitors and angiotensin II blockers while admitted to the ICU 

Design outcomes

Primary

Measure	Time frame
The primary outcome is the difference cardiac output between TBI patients with ARC and TBI patients with normal CrCl.	—

Secondary

Measure	Time frame
Renal echografic measurement: Renal perfusion, Acceleration, acceleration time and end-diastolic velocity. As well as dynamic perfusion measurements. Cystatine CInflammatory markers (leukocytes, CRP, thrombocytes)Markers of perfusion (lactate, hematocrit, central venous O2 saturation)Antibiotic concentrations	—

Countries

Netherlands

Contacts

Public ContactC. Boly

Elisabeth-TweeSteden Ziekenhuis

c.boly@etz.nl(013) 221 38 1

Outcome results