Chronic kidney disease Chronic kidney disease
Conditions
Interventions
None listed
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Chronic kidney disease groupStage 3 diagnosis: (e)GFR in the range 45-59 ml/min/1.73m2Between 18 and 70 years old> 1g proteinuria/24 hours or 100 mg/mmol creatinine on spot urine The healthy controls are matched to the CKD group, and in order for these participants to be eligible for participation, they must meet the following criteria:Age (no more than 5 years age difference) and sex matched to the CKD group.Between 18 and 70 years oldGFR > 90 ml/min/1.73m2Albuminuria < 3 mg/mmol creatinine in spot urine Kidney donor groupBetween 18 and 70 years oldNormal kidney function (which will be obvious by meeting clinical criteria to be eligible for donation)
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study:Pregnant womenWomen on their periodPresence of diabetes of any typeUncontrolled hypertensionNephrotic syndromeActive glomerular diseaseAny active infectionPresence of transurethral catheterPresence of urine deviation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine if the new technologies can be used to measure the turbidity and urine specific gravity. Compare the proxies of turbidity and urine specific gravity for kidney damage with albuminuria and total protein that are measured by the clinical laboratory using their standard equipment. Investigate how the abovementioned markers develop over time in kidney function loss in kidney donor participants. | — |
Secondary
| Measure | Time frame |
|---|---|
| Compare the use of albuminuria/total proteinuria versus the GFR of the participants. | — |
Countries
Netherlands
Contacts
Public ContactM.G. Vervloet
Radboud Universitair Medisch Centrum
Outcome results
None listed