Amyothropic Lateral Sclerosis ALS
Conditions
Interventions
nvt
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients with suspected ALS = 18 years referred to our neuromuscular outpatient clinic at the UMC Utrecht.
Exclusion criteria
Exclusion criteria: Patients with contra-indications for undergoing an MRI scan verified using MR contra-indications questionnaire (e.g. because of pacemaker, claustrophobia, metal implants, metal splinters in the eye) and with the inability to lie supine for 30 minutes for example due to respiratory difficulties.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are the presence and distribution of fasciculations measured with ultrasound and MRI. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameter(s): - EDX-derived measures that are compatible with lower motor neuron loss (e.g. fibrillation potentials, large broad polyphasic motor unit potentials), and fulfillment of diagnostic consensus criteria (Awaji and Gold Coast criteria). - Ultrasound-derived measures on muscle structure and architecture (e.g. muscle volume, echogenicity) - MRI-derived measures muscle structure and architecture (e.g. muscle volume, signal intensity). | — |
Countries
Netherlands
Contacts
Public ContactK.T. Oonk
Universitair Medisch Centrum Utrecht
Outcome results
None listed