SLE, Lupus, Systemic Lupus Eryhtematosus, Systemic Lupus
Conditions
Interventions
Not applicable.
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
No minimum to 64 Years
Inclusion criteria
Inclusion criteria: PatientDiagnosis of SLE (systemic lupus erythematosus), fulfilling the EULAR/ACR 2019 criteria.Female patients =16 years old.Wish to conceive (or =30 weeks of gestation).Written informed consent.Biological farther (to be)Written informed consent.Parents/guardians (to be), representing the childWritten informed consent.
Exclusion criteria
Exclusion criteria: All potential participants (patient, biological father, parent/guardian): Insufficient knowledge of the Dutch or English language.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To characterize the incidence of adverse pregnancy outcomes (APO) in pregnant women with SLE receiving care at a specialized center, while adhering to current treatment protocols. | — |
Secondary
| Measure | Time frame |
|---|---|
| Comprehensively examine the association of APO with disease activity, medication use, biomarkers, antibodies, immunological profiles, depression, anxiety; all before, during and after pregnancy.Describe the progression of disease activity and the immunological markers throughout these periods for woman with and without APO to understand the underlying pathogenic mechanisms.Examine pregnancy rates, time to pregnancy, and parenting physical disability in patients with SLE. | — |
Countries
Netherlands
Contacts
Public ContactR.J.E.M. Dolhain
Erasmus MC, Universitair Medisch Centrum Rotterdam
Outcome results
None listed