– Post-traumatic infections - Sepsis - Neutrophil dysfunction - Complex monotrauma
Conditions
Interventions
Dit onderzoek betreft geen nieuwe behandeling of medicatie. Het enige onderzoeksproduct is een snelle bloedtest die de functie van afweercellen (neutrofielen) onderzoekt. Deze test wordt uitgevoerd me
Sponsors
St. Antonius Ziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Trauma patients presented at the trauma bay Age: >18 (or presumed older than 18y, if age is unknown)Requirement of diagnostic blood sampling as part of the standard-of-care
Exclusion criteria
Exclusion criteria: Transferred from other hospital >3 hours after traumaTransferred to another hospital after acute trauma careCognitive impairmentImmunocompromised status (by the use of immunocompromising medicine (e.g. Methotrexaat, Infliximab, Cellcept), or by immunocompromising disease (e.g. HIV, CVID or leukemia)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severe sepsis (including septic shock) between days 3 and 30 after hospitalization (related to the acquired immunodeficiency caused by trauma). | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient and treatment characteristics from the medical record and flow cytometry data will be collected after informed consent is obtained. The parameters of interest are:Demographic informationInjury informationPre hospital informationEmergency department informationLab informationHospital procedure informationPre-existing conditionsDiagnosis informationHospital complicationsOutcome informationNeutrophil phenotype as defined by expression of neutrophil receptor markers CD16 and CD62LMean Fluorescent Intensity (MFI) of neutrophil receptors CD10, CD11b, CD16, CD62L and CD64 with and without the addition of ex vivo bacterial stimulus (fNLF) Immune related complications, as scored in the National Trauma Data Standard (NTDS)Acute respiratory distress syndrome (ARDS)Catheter-associated urinary tract infection (CAUTI)Central line-associated blood stream infection (CLABSI)Deep surgical site infectionOrgan/space surgical site infectionOsteomyelitisVentilator associated pneumoniaAny other infectious complication (not in NTDS)Non-Catheter associated urinary tract infection (NCAUTI)PneumoniaFracture related infectionSepsis | — |
Countries
Netherlands
Contacts
Public ContactT.E.E. Schiepers
St. Antonius Ziekenhuis
Outcome results
None listed