placenta insufficiency, preterm birth, placenta mosacisms
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Inclusion criteria
Inclusion criteria: in order to be eligible to participate in this study, a subject must meet all of the following criteria: Pregnant>18 yearsSingleton pregnancyGestational age > 24 weeksBirth at the Wilhelmina’s Children HospitalAnd for the placenta-related complications or imminent preterm labor must meet one of the definitions below: PIH:Diastolic blood pressure >90 mmHg and/or systolic >140 mmHg, measured twice with a minimum interval of 6 hours Preeclampsia:PIH with proteinuria (EKR > 30 mg/mol) OR PIH with organ dysfunction including kidney dysfunction (creatinine > 90 umol/L), liver damage, neurological symptoms or hematologic abnormalities OR PIH with FGR HELLP:Hemolysis, liver function abnormalities and thrombocytopenia FGR:Estimated fetal weight (EFW) and/or abdominal circumference (AC) <p10 PPROM:Positive fern test and/or clinical diagnosis (e.g. objectified fluid loss/oligohydramnios)Cervix shortening:Cervix length < 2.5cm
Exclusion criteria
Exclusion criteria: - Confirmed fetal chromosomal abnormalities - Fetal infections (e.g. CMV) - Multifetal pregnancy - No informed consent - Fetal structural anomalie
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Adverse Pregnancy and birth outcomes/complications in relation to cfDNA characteristics in the second half of pregnancy | — |
Secondary
| Measure | Time frame |
|---|---|
| - Neonatal morbidity/mortality - Severity of maternal disease - Duration until delivery (i.e. pregnancy complication-delivery interval) - Added value of cfDNA characteristics other than fetal fraction - Added value of cfRNA characteristics | — |
Countries
Netherlands
Contacts
Public ContactM.N. Bekker
Universitair Medisch Centrum Utrecht
Outcome results
None listed