Hemophilia A
Conditions
Interventions
Participants will be exposed to stress-inducing and relaxing VR content during two separate study visits, the Relax Visit and the Rollercoaster Visit. Blood samples will be collected immediately befor
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Age between 18 and 45 years old;Willing and able to provide written informed consent.
Exclusion criteria
Exclusion criteria: A history of motion- or cybersickness;Fear of needles; Any of the following haematological disorders:Congenital or acquired haemophilia A;Von Willebrand Disease.Any of the following endocrinological disorders:Thyroid disorders (e.g. hypo/hyperthyroidism);Cushing syndrome;Adrenal insufficiency;Diabetes mellitus type 1 or 2;Central or nephrogenic diabetes insipidus. A confirmed cardiac disorder;All types of epilepsy;Every form of medication, except for intermittent use of pain killers but not in the last day (e.g. paracetamol) and an intra-uterine device with or without contraceptive;Pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The difference in stress-related biomarkers (factor VIII activity, vWF ristocetin co-factor activity, copeptin (AVP), prolactin, thyroid stimulating hormone (TSH), cortisol and glucose) measured before and after relaxing and stress-inducing VR-content, in order to compare biomarker changes under the influence of different types of VR-content. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secundary outcomes consist of the comparison of the two correlations between relaxing and Vr content., the occurence of objective stress during VR content and the occurence of subjective stress during VR content. | — |
Countries
Netherlands
Contacts
Public ContactA.D.W. Vos
Universitair Medisch Centrum Utrecht
Outcome results
None listed