social domain, quality of life
Conditions
Interventions
Participants will be randomly assigned to two groups: one group will take their loop diuretic in the morning for the first 2 weeks, followed by 2 weeks in the afternoon, while the other group will tak
Sponsors
Amsterdam UMC
Eligibility
Age
65 Years to 99 Years
Inclusion criteria
Inclusion criteria: Age =65 years Stable chronic heart failure (heart failure outpatient clinic or primary care) Use of once-daily furosemide or bumetanide (irrespective of dosage)
Exclusion criteria
Exclusion criteria: Heart failure related hospitalization =3 months ago, or diuretic dose adjustment =30 days of inclusion Patients with indwelling catheters or urostomy catheter Patients with narrow angle glaucoma Patients who the researchers deem incapable to make an (informed) decision about participating in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is disease-related quality of life, measured using relevant items from the validated RAND-36/SF-36. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes include:Perceived heart failure burden, assessed using the Kansas City Cardiomyopathy Questionnaire (KCCQ).Physical functioning as a subdomain of the RAND-36/SF-36.Sleep quality, measured with the Insomnia Severity Index (ISI).Weight.Frequency of nocturia.Fall incidents.Unplanned hospital admissions or emergency/urgent care visits due to heart failure. | — |
Countries
Netherlands
Contacts
Public ContactEP Poelgeest
Amsterdam UMC
Outcome results
None listed