Stress
Conditions
Interventions
The study contains a 6-week intervention with six parallel arms: 1) Probiotic supplement, 2) Nutri-biotic supplement, 3) Fiber supplement A, 4) Fiber supplement B, 5) Fiber supplement C, and 6) Placeb
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Apparently healthy adult (25-40 years)BMI 18.5 – 30 kg/m2 (self-reported)Willing to keep diet and physical activity levels stable during the study period
Exclusion criteria
Exclusion criteria: Personal history of psychiatric, neurological, gastrointestinal, endocrine disorders, and relevant medical history (self-reported)People with high anxiety or depression levels, based on the GAD7 questionnaire (score =8) and the PHQ-4 questionnaire (score =3 on anxiety or depression sub-score)Regular medication use that may impact the study outcomes, as assessed by the medical investigator (self-reported)Pre-, post- or probiotic supplementation (stop at least 4 weeks for study start)Smoking (stop at least 4 weeks for study start)Using recreational drugs (stop at least 4 weeks for study start)Use of antibiotics within 3 months before the start of the studyFood intolerance (cow’s milk, lactose or prebiotics)Excessive alcohol consumption (>14 glasses per week)Contra-indication for cold pressor test (Raynaud’s phenomenon, chronic pain syndrome in shoulder or arm, open wounds on arm or hand, scleroderma, arteriovenous fistula or shunt, presence of (unstable) angina pectoris).Being pregnant or breastfeeding Working at Food Health and Consumer Research group of Wageningen Food and Biobased Research, FrieslandCampina, Anibiome, Danone Research, Tate&Lyle, Ingredion, MyMicroZoo, Donders institute, or Mavenhealth
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is working memory, measured using the backward digit span task. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters are sustained attention as measured by the vigilance task, stress, sleep quality, and faecal microbiota composition. | — |
Countries
Netherlands
Contacts
Public ContactL Janssen Duijghuijsen
Wageningen Universiteit
Outcome results
None listed