Healthy participants with overweight
Conditions
Interventions
Eight consecutive weeks of, three times per week, 20 min far-infrared sauna (70ºC) exposure followed by 2 min cold-water immersion (±14ºC) (2x/day), with each session separated by ten minutes of rest
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Men or womenWomen who are pre-menopausal (steady menstrual cycle) or at least one year post-menopausalWhite western EuropeanAge: 40-75 yearsBMI 27.5-35 kg/m2Steady dietary habits (no weight loss or gain of more than 5 kg in the past 3 months)Sedentary lifestyle (<2h exercise/week)Generally healthy, no medication use that interferes with metabolism.
Exclusion criteria
Exclusion criteria: Type 2 DiabetesMen haemoglobin <8.4 mmol/L; women haemoglobin <7.8 mmol/LSigns of active hypertension, liver or kidney malfunctionCardiac problems and cardiovascular diseasesMedical conditions requiring treatment and/or medication that might interfere with the investigated parameters (beta-blockers, thyroid medication, stimulants, antidepressants, anticoagulants, hormonal treatments).Unstable body weight (weight gain or loss >3 kg in the past three months)Recent participation in another biomedical study (less than 1 month)Participants who do not want to be informed about unexpected medical findings, or do not wish that their treating physician will be informedSmoking (in the past six months) or alcohol abuse (>2 servings per day for men; >1 serving per day for women)Taking hot baths/saunas and/or cold water/ice baths regularly (more than once per four weeks)Women who are in their menopause
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary study outcomes of glucose homeostasis include glucose tolerance and insulin sensitivity (HOMA-IR, Matsuda ISI, HIRI and MISI). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters include thermophysiological measures (core and skin temperature and sweat loss), cardiovascular (heart rate, blood pressure, arterial stiffness, plasma volume, endothelial function, cutaneous blood flow, maximum heat-induced vasodilation and microvascular function) and metabolic parameters (fat metabolites, renal and liver function), inflammatory markers, functional outcomes (CPET and handgrip strength), muscle structure (capillarisation, fibre size and heat shock protein expression), body composition, subjective perception (thermal acceptability, sensation, comfort and preference) and mental well-being (PANAS, DASS-21). | — |
Countries
Netherlands
Contacts
Public ContactV Haan
Universiteit Maastricht
Outcome results
None listed