Psoriasis
Conditions
Interventions
The intervention we are researching is autofluorescence-guided laser treatment for psoriasis spots.
Sponsors
ZBC MultiCare
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Diagnosis of psoriasis vulgaris of any severity with at least three discrete lesions in optically non-obscured skin located on torso, abdomen, dorsum, legs, arms, face or buttocks. Age between 18–64 years. Fitzpatrick Skin type 1 - 3 Patients may continue other treatment regimens during the study.
Exclusion criteria
Exclusion criteria: Pregnancy or breastfeeding. Reumatoid arthritis psoriatic arthritisKnown allergy to 5-aminolevulinic acid (5-ALA) or light sensitivity. Autoimmune disorders. Heavy smoking. Diabetes mellitus type 2 Active bacterial or viral infections in the treatment area Recent use of isotretinoin Morbid obesity History of hypertrophic scaring or keloids History of complicated wound healing Body dysmorphic disorder Use of anti-coagulants Use of cyclosporin A or similar immunosuppressive medication Increase in disease severity during the preceding 8 weeks. If treatment area is on the legs: Severe venous insufficiency, severe lymphoedema or angiopathy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the feasibility and effectiveness of enhanced autofluorescence-guided ER:YAG laser resurfacing for treating psoriatic plaques. | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the reliability of the change in PpIX fluorescence intensity as an indicator for complete epidermal removal, clinical improvement (PGA and 0-1 remission score), remission duration, recurrence rates, healing time, and patient-reported outcomes. | — |
Countries
Netherlands
Contacts
Public ContactN. Beek
ZBC MultiCare
Outcome results
None listed