carotid atherosclerotic plaques
Conditions
Interventions
Patients will receive an intravenous injection of 0.5mg/kg ICG, and imaged with MSOT in the two hours prior to CEA. 
This MSOT imaging procedure will take approximately 15 minutes ande is comparable to a clinical ultrasound investigation of the carotid artery in supine position. Surgery is performed according to sta
will be transported to the pathology department to make ex vivo fluorescence images to visualize ICG. It will subsequently be snap frozen and transported to Erasmus MC for scanning in the MSOT (iThera
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients undergoing carotis endarterectomy. Patients must be > 18 years old and be able to give informed consent.
Exclusion criteria
Exclusion criteria: Major surgery within 28 days before tracer administration.Pregnant or nursing women, fertile women will need a negative pregnancy test prior to inclusion.History of iodine allergy or anaphylactic reactions to insect bites.Hypersensitivity to ICG or poorly tolerated ICG in the past.Unexplained allergic reaction in the past.Skin type > IV following Fitzpatrick skin classification (MSOT less reliable).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main outcome is the technical feasibility of non-invasive optoacoustic imaging of ICG in carotid artery plaque. The findings are compared with ex vivo MSOT and fluorescence imaging results and histopathological analysis of the excised specimen. | — |
Secondary
| Measure | Time frame |
|---|---|
| see above | — |
Countries
Netherlands
Contacts
Public ContactJ. Vonk
Universitair Medisch Centrum Groningen
Outcome results
None listed