acute kidney injury, acute on chronic kidney injury, chronic kidney disease
Conditions
Interventions
The intervention group will receive CVVHDF with a distribution between convective and diffusive flow of approximately 50%/50%. The control group will receive CVVHDF (distribution between convective an
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a participant must meet all of the following criteria:18 years or older CRRT indicationAcute or (acute on) chronic renal failure
Exclusion criteria
Exclusion criteria: A potential participant who meets any of the following criteria will be excluded from participation in this study:CRRT for intoxication(Risk of/ probable) elevated intracranial pressureSevere hyponatremia < 125 mmol/lSevere hypernatremia >155 mmol/lPregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study endpoint is the CRRT circuit survival time. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints are the rate of metabolic correction, CRRT treatment duration in hours and the circuit performance. Metabolic correction will be studied by evaluating the courses of potassium, phosphate, pH, HCO3- and urea. Filter performance will be studied by evaluating the clearance of beta-2 microglobulin and the ratio of urea in the effluent fluid and in the patients plasma (4). | — |
Countries
Netherlands
Contacts
Public ContactM. Volbeda
Universitair Medisch Centrum Groningen
Outcome results
None listed