General Risk factors And iNflammatory Determinants in older patients with asthMA: the GRANDMA study

General Risk factors And iNflammatory Determinants in older patients with asthMA: the GRANDMA study - GRANDMA-study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON57818

Enrollment

150

Registered

2017-02-22

Start date

2017-05-08

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthma

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria asthma: - Age between 18-80 years - Smoking history of 50 ppb. - All asthma patients have GINA step 4-5 medication (high dose ICS/LABA). - ACQ > 0,75 - Written informed consent.;Inclusion criteria healthy control: - Wirtten informed consent - Age between 18-80 years.

Exclusion criteria

Exclusion criteria: Exclusion criteria asthma: - Smoking history of > 10 PY - Age 80 years - Not able to speak or write Dutch language. - Not able to perform lung function test/sputum induction - ACQ

Design outcomes

Primary

Measure	Time frame
To compare the differences in number and activation status of inflammatory cells (eosinophils, neutrophils, T-cell subsets, DC*s, ILC2 cells) in sputum and blood of different subgroups of asthmatics (early vs late onset, older vs younger).	—

Secondary

Measure	Time frame
- To find correlations between ILC2 numbers and characteristics and immunological and clinical disease phenotype. - Detection of microflora/microbiome pattern in sputum and faeces in different subgroups of asthmatics and compare with controls. - Detection of cortisol levels in hair, to determine a possible method to check ICS adherence. - To measure physiological factors (lung function, activity level) and relate them to inflammatory profile. - To investigate the relationship between duration and onset of asthma and self-management/coping strategies of patients. - To study the effect of aging on inflammation, physiology, psychology and co-morbidities in asthma.	—

Measure

Time frame

- To find correlations between ILC2 numbers and characteristics and immunological and clinical disease phenotype. - Detection of microflora/microbiome pattern in sputum and faeces in different subgroups of asthmatics and compare with controls. - Detection of cortisol levels in hair, to determine a possible method to check ICS adherence. - To measure physiological factors (lung function, activity level) and relate them to inflammatory profile. - To investigate the relationship between duration and onset of asthma and self-management/coping strategies of patients. - To study the effect of aging on inflammation, physiology, psychology and co-morbidities in asthma.

—

Countries

Netherlands

Outcome results