anxiety disorders stress disorders
Conditions
Interventions
One group receive on day 2 of the study a single dose of 40mg propranolol. The
other group receives a single dose of placebo.
Sponsors
Radboud Universiteit Nijmegen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Age: 18 to 35 years - Predominantly right-handed - Normal or corrected-to-normal vision - Normal uncorrected hearing - Willingness and ability to give written informed consent and willingness and ability to understand the nature and content, to participate and to comply with the study requirements.
Exclusion criteria
Exclusion criteria: - History of psychiatric treatment or current psychiatric treatment. - History of neurological treatment or current neurological treatment. - History of endocrine treatment or current endocrine treatment. - History of autonomic failure (e.g., vasovagal reflex syncope). - Metal objects in or around the body (braces, pacemaker, metal fragments, hearing devices). - Claustrophobia. - Abnormal hearing or (uncorrected) vision. - History of psychotropic medication (especially anti-depressants) - Average use of recreational drugs weekly or more. - Use of medication (other then paracetamol or ibuprofen) or of recreational drugs over a period of 72 hours -, and use of alcohol within the last 24 hours prior to study. Additional exclusion criteria for propranolol: - History of heart related disease - A-V block (PR interval longer than 0.20sec or irregular PR intervals) - Sinus bradycardia (heart rate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - funtional MRI - skin conductance responses | — |
Secondary
| Measure | Time frame |
|---|---|
| - Mood state questionnaires - bloodpressure | — |
Countries
Netherlands
Outcome results
None listed