depression mood disorder
Conditions
Interventions
Patients in the intervention and control group will receive usual care by their
psychiatrists or
psychologists. Additionally patients in the intervention group will be enrolled
in a six months (40 s
Sponsors
Symforagroep (Amersfoort)
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: age 18 -65 years DSM-IV diagnosis: unipolar of bipolar depression baseline score Hamilton Rating Scale of Depresion (HRSD) >
Exclusion criteria
Exclusion criteria: - patients with comorbid psychiatric disorders - patients in longstay facilities or with complex pathology - significant cardiovascular disease or other medical conditions which contra- indicates exercise therapy - contraindications for walking and/or running - addiction to alcohol and other drugs as a primary diagnosis - high suicide risk - regular physical exercise (2-3 times a week on a high-intensity)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measure is reduction in depressive symptoms as measured with the Hamilton Rating Scale for Depression (HRSD). It is expected that patients in the usual care group will respond with a mean reduction of 6 points compared to 8 points for the intervention group on the HRSD. | — |
Secondary
| Measure | Time frame |
|---|---|
| Metabolic syndrome will be evaluated by a physical test and blood samples including BMI, waist circumference, systolic and diastolic blood pressure, fasting glucose, triglycerides, cholesterol/HDL-ratio, creatinine and Cockroft clearance; Quality of life by the WHO-DAS questionnaire and cost effectiveness by the TIC-P questionnaire, the EUROQOL and a VAS for subjective health. | — |
Countries
Netherlands
Outcome results
None listed