Hookworm infection parasitic infection Abdominal worminfection
Conditions
Interventions
Five volunteers will be exposed to 50 Necator americanus L3 larvae, after which
they will be treated with a curative regimen of albendazole after two weeks.
Then, they will be inoculated with a lowe
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: 1. Subject is aged >= 18 and
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: 1. Any history, or evidence at screening, of clinically significant symptoms, physical signs or abnormal laboratory values suggestive of systemic conditions, such as cardiovascular, pulmonary, renal, hepatic, neurological, dermatological, endocrine, malignant, haematological, infectious, immune-deficient, psychiatric and other disorders, which could compromise the health of the volunteer during the study or interfere with the interpretation of the study results. These include, but are not limited to, any of the following: • positive HIV, HBV or HCV screening tests; • the use of immune modifying drugs within three months prior to study onset (inhaled and topical corticosteroids and oral anti-histamines exempted) or expected use of such during the study period; • having one of the following laboratory abnormalities: ferritine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Identification of effector cells in the skin by Hyperion Imaging Mass Cytometry after repeated controlled hookworm infections - Association between the macroscopic skin reaction and effector cells present identified by Hyperion Imaging Mass Cytometry | — |
Secondary
| Measure | Time frame |
|---|---|
| - Measurement of humoral (antibody responses and cytokines) and cellular immunological changes after controlled hookworm infections - Detection of hookworm eggs by faeces microscopy (Kato-Katz) at week 15-16 in volunteers who volunteered to be chronic donors Endpoints for exploratory objectives: - Number of adverse events following exposure(s) to hookworm larvae | — |
Countries
Netherlands
Contacts
Public ContactM. Hoogerwerf
Leids Universitair Medisch Centrum
Outcome results
None listed