Producing insulin-producing cells from stem cells of patients with severe diabetes

Generation of induced Pluripotent Stem Cells from patients with severely complicated insulin-deficient diabetes - MIsletPSC - Generation One

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON57750

Enrollment

Registered

2024-05-10

Start date

2026-02-03

Completion date

Unknown

Last updated

2026-02-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diabetes, diabetes mellitus

Interventions

Not applicable.

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: • Insulin-deficient diabetes based on random C-peptide values 69 mmol/mol Hb) and/or impaired hypoglycaemia awareness and/or recurrent (severe) hypoglycaemic events during the past year and/or hospital admission for glycaemic dysregulation during the past year • Previous donor pancreas or islet transplantation • Plasma reactive antigens (PRA) > 90%

Exclusion criteria

Exclusion criteria: • Unable to understand or provide written informed consent

Design outcomes

Primary

Measure	Time frame
iPSC line characterized by the absece of residual episomal factors, the presence of indicators of an undifferentiated iPSC stage, and the ability to differentiate in all 3 germ cell lineages.	—

Countries

Netherlands

Contacts

Public ContactEJP de Koning

Leids Universitair Medisch Centrum

e.dekoning@lumc.nl0715262085

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP) · Data processed: Feb 19, 2026