cervix/vulva cancer Head and neck cancer
Conditions
Interventions
None listed
Sponsors
Antoni van Leeuwenhoek Ziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a patient must meet all of the following criteria: a. Histologically proven cervical, vulvar or oropharyngeal cancer. b. Age above 18 years c. Performance score WHO 0, 1, or 2 at time of study entry d. Written informed consent e. An indication and fit for a routine investigation under general anesthesia or for therapeutic or palliative surgery during which a tumor biopsy can be taken (tumor volume *0.2 cm3) or the presence of metastatic lesion(s) of which a histological biopsy can safely be obtained (expected biopsy volume *0.2 cm3) * I. Patients with safely accessible metastases according to an intervention-radiologist. II. Patients not known with bleeding disorders (such as hemophilia) or bleeding complications from biopsies, dental procedures or surgeries.;*These criteria are only applicable if the patient ticked ICF for biopsies.
Exclusion criteria
Exclusion criteria: D5a. In het Engels a. Anemia (Hb
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| This study is not an intervention study. The main study endpoint is the isolation of TCRs from HPV-reactive and CT-antigen-reactive T-cells from tumor tissue and/or blood. | — |
Secondary
| Measure | Time frame |
|---|---|
| More insight in the correlation between HPV-reactive and other tumor-reactive T-cells found in the tumor to those found in the blood. This can help to improve strategies for future TCR isolations. | — |
Countries
Netherlands
Outcome results
None listed