primary aldosteronism primary aldosteronism
Conditions
Interventions
response of renin and aldosterone to salt loading
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: healthy male and female subjectsnormal blood pressure, i.e. office systolic blood pressure < 140 and diastolic blood pressure < 90 mmHg
Exclusion criteria
Exclusion criteria: hypertension (systolic blood pressure > 140 mmHg and/or diastolic blood pressure > 90 mmHg past medical history of heart failure, myocardial infarction, stroke, TIA, peripheral arterial disease or adrenal gland disorderelevated liver enzymes (ALAT/ASAT/gammaGT/AF > 1.5 times URL)renal insufficiency (eGFR < 60 mL/min/1.73m2 ) diabetes mellitus (any type) pregnancyuse of one of the following drugs: ACE- inhibitors,angiotensin receptor blockers, renin blockers, calcium channel blockers, diuretics, betablockers, alphablockers, centrally acting antihypertensives (like clonidine, moxonidine, methyldopa), nonsteroidal anti-inflammatory drugs, potassium supplements, glycyrrhizin containing products
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 95% confidence intervals of renine and aldosterone before and after a 3-day oral salt loading test. | — |
Secondary
| Measure | Time frame |
|---|---|
| conversion factors between the assays for determination of renin and aldosterone | — |
Countries
Netherlands
Contacts
Public ContactMN Kerstens
Universitair Medisch Centrum Groningen
Outcome results
None listed