Vitamin A deficiency Vitamin A deficiency
Conditions
Interventions
At day 0, a dose of 6 µmol (~2 mg) 13C10-retinyl acetate will be administrated 
orally by means of a capsule filled with oil. Unlabelled vitamin A supplements 
(3 mg/d) will be consumed by subjects from day 60 till 80 to prompt a decrease 
in plasma retinol specific activity.
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: FemaleAge: 18-45 yearsNon-smokingWilling to consume VA supplements for 21 days
Exclusion criteria
Exclusion criteria: A potential subject will be excluded from the study due to:Pregnancy or lactating (Pregnancy test (urine hCG) =72 hours before start Day 60; when in doubt, serum hCG confirmation).Self-reported history of metabolic, gastrointestinal, kidney or chronic disease such as diabetes, renal failure, hepatic dysfunction, hepatitis, hypertension, cancer or cardiovascular diseasesReduced kidney function (glomerular filtration rate <90ml /min per 1.73 m2)Reduced liver function (alkaline phosphatases (> 240 IU/L), AST (> 40 IU/L), ALT (> 40 IU/L) and gamma glutamyl transferase (> 50 IU/L))Self-reported hypercholesterolemiaContinuous/long term use of medication during whole studies (except for contraception)Disorder or use of drugs that interferes with fat-soluble vitamin absorption Blood transfusion, recent major surgery, blood donation (< 6 months ago) Use of (multi)vitamin preparations with VA or ß-carotene up till 3 months before the start of the studyDieting or having irregular dietary habitsNot willing or afraid of having blood drawn Participation in another clinical trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary study parameters will be specific activity (SAp), fraction of the administered isotope dose circulating in plasma (FDSAp), plasma retinol concentrations and total body stores (TBS). | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary study parameters will be inflammatory marker (C-reactive protein (CRP), and dietary energy and vitamin A intake. | — |
Countries
Netherlands
Contacts
Public ContactT.L Chimhashu
Wageningen Universiteit
Outcome results
None listed