Obesitas Asthma bronchial hyperreactivity
Conditions
Interventions
None listed
Sponsors
Sint Franciscus Gasthuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: All patients who fullfilled the inclusion criteria at the time of inclusion in 2008 will be invited for particpation. There are no new criteria for inclusion. They must be able to perform a reproducible lung function test. ;At the moment of inclusion in 2008 (OBAS 1.0) • For the asthma patients: physician diagnosed, persistent asthma > 2 years • Age > 18 and 35 kg/m2 • Ability to perform a reproducible lung function test
Exclusion criteria
Exclusion criteria: Patients will be excluded if they have other significant pulmonary pathology and if they are pregnant. ;At the moment of inclusion 2008 (OBAS 1.1) • Smoking > 10 sig/d or > 10 pack years (PY) • COPD or other pulmonary pathology apart from asthma. • Pregnancy • Exacerbation in 4 weeks prior to screening • Psychological instability
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Asthma Control Questionnaire (ACQ) and Asthma Quality of Life Questionnaire (AQLQ) at 8 years after bariatric surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| • Lung function parameters: FEV1, FVC, FEV1/FVC TLC, FRC, reversibility. R5, X5 and Fres (IOS). • Airway hyperresponsiveness: PD20 (methacholine) • Airway inflammation: FeNO • Systemic inflammation (blood): TNF-a, IL-6, high sensitivity CRP, leptin and adiponectin • Asthma symptoms, exacerbation frequency, medication use | — |
Countries
Netherlands
Outcome results
None listed