cognitive disorder dementia
Conditions
Interventions
n.v.t.
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Adult patients with: • Clinical suspicion of mixed pathology • Mini Mental State Examination (MMSE) score >= 20 • Clinicians making the patients aware of the current study will judge whether the participant is mentally compentent • Clinical Dementia Rating scale (CDR) score 0.5-1, and • Availability of an MRI scan, and • Availability of plasma (plasma can be collected as part of- or outside of regular care, participants can only take part in the study if they are able to give plasma for the purpose of this study)
Exclusion criteria
Exclusion criteria: • Normal Pressure Hydrocephalus, or Morbus Huntington, • Brain tumor, epilepsy, encephalitis, • Primary psychiatric disorders such as schizophrenia, bipolar disorder or psychotic problems (NAO), major depressive disorder (within 12 months) (DSM-5), • Alcohol or other substance abuse (clinical judgement).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study parameters/endpoints: 1. Change in rating on the assumed underlying pathologies before and after release of the disease specific biomarkers. 2. Confidence of the clinician in the rating of assumed underlying pathologies before and after presentation of disease-specific biomarkers. 3. To explore the clinical experts' experiences with the use of these disease-specific biomarkers. | — |
Countries
Netherlands
Contacts
Public ContactS Duijkers
Universiteit Maastricht
Outcome results
None listed