dementia Neurodegenerative disorder
Conditions
Interventions
None listed
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Individuals of at least 18 years of age with pathogenic mutations leading to autosomal dominant Alzheimer's disease as confirmed by genetic counseling and with baseline MEG.
Exclusion criteria
Exclusion criteria: Individuals who are or have been treated with (potentially) disease modifying therapies after baseline MEG. Individuals who are not able to travel to the Alzheimer Center Amsterdam or have severe contraindications for undergoing MEG.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are obtained by MEG recordings: for both eyes closed, and eyes open resting state, as well as during a working memory task and during light sleep stage. - Hippocampal and whole brain MEG-based measures of oscillatory brain activity, represented as absolute broadband power. - Hippocampal and whole brain MEG-based measures of excitation/inhibition balance (E/I) by the analysis of aperiodic signals (1/f) and the detrended fluctuation analysis (DFA) applied to the amplitude envelope of the conventional frequency bands as proposed measure of E/I ratio (described in Figure 4). | — |
Secondary
| Measure | Time frame |
|---|---|
| - MEG-based measures of oscillatory activity, functional connectivity and network measures in specific frequency bands. - Cognitive performance by score from neuropsychological tests and MMSE and short working memory test during MEG - Structural MRI measurements, such as diffusion tensor imaging (DTI) for structural brain networks characterization, Grey and White matter (G/WM) volumes, FLAIR/SWI for white matter hyperintensities / micro bleeds. - AD biomarkers using CSF based protein concentrations, specifically Aß1-42, total tau and phosphory-lated tau. - Demographics like age, sex, parental age at diagnosis and/or symptom onset, education, mutation type, subjective cognitive complaints and changes, self-reported depression/anxiety, and daily life functioning. | — |
Countries
Netherlands
Outcome results
None listed