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Evaluation of the variability of total blood volume measurements on the basis of the change in relative blood volume measured with the blood volume monitoring module of the Fresenius dialysis machine after bolus infusion of ultrapure dialysate.

Evaluation of the variability of total blood volume measurements on the basis of the change in relative blood volume measured with the blood volume monitoring module of the Fresenius dialysis machine after bolus infusion of ultrapure dialysate. - Evaluation of variability of absolute blood volume measurement

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
NL-OMON
Registry ID
NL-OMON57645
Enrollment
38
Registered
2025-06-12
Start date
2025-12-02
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Accurate en precise estimation of blood volume

Interventions

The intervention consists of the measurement of total blood volume during six consecutive hemodialysis sessions Original protocol: In the previous study measurement of ABV was performed during the m

Sponsors

HagaZiekenhuis
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Zie blz 11/25: Patients undergoing chronic hemodialysis treatment at the Haga Hospital in either The Hague, or Zoetermeer. 4.2 Inclusion criteria In order to be eligible to participate in this study, a subject must meet all of the following criteria: Patients on stable HDF for > 3 months with a stable target weight for >= 1 month who are at target weight by the end of dialysis for at least the second and third dialysis of the week with average ultrafiltration requirements of = 18 years. Thrice weekly hemodialysis schedule. Signed informed consent prior to participation

Exclusion criteria

Exclusion criteria: Clinically significant heart-, or liver failure, ultrafiltration requirements > 3,4 l/session, residual diuresis resulting in the absence of requirement for ultrafiltration, clinically significant fistula dysfunction resulting in spKtV

Design outcomes

Primary

MeasureTime frame
he primary outcome measure is the repeatability coefficient defined as 1.96 x *2 x within-subject SD. The within-subject standard deviation is derived from the variance calculated using a one-way ANOVA of the dataset, where the data pairs are always 38 1st, 38 2nd and 38 3rd dialyses of the week. We aim for a repeatability coefficient of 6-7 ml/kg, which corresponds to a measurement error of 10%.

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)