Depression/major depressive disorder/dysthemia
Conditions
Interventions
The standard treatment for depression and DSRD will be evaluated.
Sponsors
Amsterdam UMC
Eligibility
Age
2 Years to 64 Years
Inclusion criteria
Inclusion criteria: Individuals with a phenotypical diagnosis of Down syndrome.Age 40 years or younger at the time of enrollment.A current (probable) diagnosis of depression (with or without catatonia) or DSRD as diagnosed by a physician with expertise in this patient population.Availability of a parent or caregiver who has known the patient premorbid and can provide proxy-reported outcomes regarding the patient's behavior over the past six months.
Exclusion criteria
Exclusion criteria: A previously diagnosed genetic, metabolic and/or neurological disorders which can contribute to the neuropsychiatric symptoms.No informed consent contained from the patient (if legally capacitated) or their parents, guardian or legal representative (if not legally capacitated).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anxiety, Depression and Mood Scale; in Dutch: Angst, Depressie En Stemming Schaal (ADESS) | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient-reportedOttawa Mood Scales (OMS)Proxy-reportedLanguage Production scale (LP-scale)Neuropsychiatric Inventory Questionnaire (NPI-Q)Vineland Adaptive Behavior Scale 3rd Edition, Dutch version (VABS-3-NL)Goal Attainment Scale (GAS)Dual-reportedGenetic Intellectual Disability - Patient Reported Outcome Measures (GID PROM)-setOtherLevel of blood biomarkers for neurodegeneration and AD (e.g., NfL) | — |
Countries
Netherlands
Contacts
Public ContactA.M. Eeghen
Amsterdam UMC
Outcome results
None listed