psychotic disorder
Conditions
Interventions
No intervention
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
No minimum to 64 Years
Inclusion criteria
Inclusion criteria: All pregnant women and their partners: • At least 18 years old • Ability to provide informed consent • Singleton pregnancy Pregnant women and their partners with at least one (future) parent with SMI: • At least one (future) parent with SMI in the mood-psychosis spectrum diagnosed before current pregnancy, i.e., schizophrenia, bipolar disorder, severe MDD (i.e., with high recurrence rate and/or hospitalizations), psychosis NOS, single psychosis
Exclusion criteria
Exclusion criteria: All pregnant women: • Postpartum psychosis (after a prior pregnancy), unless diagnosed with SMI prior to the postpartum psychosis All pregnant women and their partners: • Substance use disorder (alcohol, drugs), active < six months pre-pregnancy as assessed with R4U or current addiction treatment, such as methadone or buprenorphine • Suspicion of intellectual disability or syndromes or genetic abnormalities known to affect neurodevelopment All infants/toddlers: • Preeclampsia or foetal growth restriction at time of inclusion • Neurological illness or structural brain abnormalities • Suspected congenital anomalies or syndromes or genetic abnormalities known to affect neurodevelopment • Chromosomal abnormalities • Genetic abnormalities known to impact neurodevelopment • Premature birth (< 37 weeks) Pregnant women and their partners without SMI: • A lifetime diagnosis of SMI in the mood-psychosis spectrum as assessed with the Mini-International Neuropsychiatric Interview (M.I.N.I.; (Sheehan et al., 1998). • Postpartum psychosis (after a prior pregnancy) • An SMI in the mood-psychosis spectrum in their first-degree relatives • Use of neurotrophic medication In all (future) parents, (co)morbidity with other psychiatric diagnoses is not an exclusion criterion, except for substance use disorder.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Socioemotional functioning in 18-month-old infants of parents with or without SMI operationalised as visual social attention (%initial look; %attention) obtained via eye tracking. | — |
Secondary
| Measure | Time frame |
|---|---|
| Exploration of differences between offspring from parents with vs. without SMI, using follow-up questionnaires, blood/saliva and hair samples to measure: • parent-child dynamics (over time) • child temperament (over time) • child socioemotional development • PGR scores for SMI • Hair cortisol levels And explore the role of these factors in social-emotional functioning as measured by eye-tracking (i.e., primary endpoint). | — |
Countries
Netherlands
Contacts
Public ContactN Haren
Erasmus MC, Universitair Medisch Centrum Rotterdam
Outcome results
None listed