Heart failure
Conditions
Interventions
 
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Aged = 18 yearsCapable of understanding and signing informed consentPatients with cardiac disease who are clinically stable OR Healthy volunteers
Exclusion criteria
Exclusion criteria: Subjects who live abroad or who are not Dutch speakingSubjects with inability to obtain adequate echocardiographic examinationPregnant and/or lactating women Healthy subjects with: (prior) cardiovascular disease; cardiovascular risk factors consisting of hypertension, diabetes mellitus or hypercholesterolemia; systemic disease or medication known to influence cardiac function; or the findings of cardiac abnormalities during examination; professional athletes; morbidly obesity (BMI >40 kg/m2), pregnant women and women with breast implants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary study endpoint is the comparison of measurement values between patients with various cardiac pathologies and healthy controls, aimed at evaluating the value of these recent imaging techniques in the field of cardiac imaging. The slope of the systolic strain-volume relation (S-slope) and uncoupling of the systolic and diastolic strain-volume relation (UNCOUP) will be derived from SV-loops. For RV shape and function, mean RV curvature and area strain will be calculated. Using SWI, myocardial shear wave velocities will be measured during diastole, and after aortic and mitral valve closure. Feasibility of the imaging techniques will be assessed by the rate of acquisition of adequate imaging and the ability to derive subsequent parameters. | — |
Secondary
| Measure | Time frame |
|---|---|
| Investigate feasibility, reproducibility and clinical applicability of new imaging techniques (SV-loops, 3D RV beutels, SWI) | — |
Countries
Netherlands
Contacts
Public ContactA.E. van den Bosch
Erasmus MC, Universitair Medisch Centrum Rotterdam
Outcome results
None listed