depression mood disorder depression
Conditions
Interventions
None listed
Sponsors
Amsterdam UMC
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Age 18 years or older • Receiving voluntary clinical or outpatient treatment at the Amsterdam UMC, GGZ InGeest or UMCU. • Having a (suspected) diagnosis of major depressive disorder and is (planned) to be treated with ECT not later than four weeks after recruitment. • Fluent in Dutch
Exclusion criteria
Exclusion criteria: • Previous claustrophobic or anxiety experiences while enclosed in a room of similar size as the magnetically shielded room • Metal implants not compatible with OPM-MEG or MRI. • Suspicion or diagnosis of neurodegenerative disorders, such as dementia • Cognitive disorder not explained by the depressive episode.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is hippocampal neurophysiological resting-state activity that may include, but is not limited to, power (aperiodic) frequency spectrum analysis (e.g. theta and gamma power). | — |
Secondary
| Measure | Time frame |
|---|---|
| Our secondary endpoints are correlation between (change in) neurophysiological resting-state activity from the hippocampus with cognitive side effects, and depressive symptom reduction due to ECT. | — |
Countries
Netherlands
Contacts
Public ContactA Hillebrand
Amsterdam UMC
Outcome results
None listed